Anavar is a well known steroid used by the fitness and bodybuilding community, but there are a few aspects that make Anavar a truly unique and special Anabolic steroid.
Oxandrolone is an orally modified version of Dihydrotestosterone (DHT) its C 17 Alpha-Alkylated steroid, that means its been refined and altered to survive first pass through the liver and therefore deliver its affects, its assimilated very quickly and becomes active straight away.
Its half life is around 9 hours, so splitting up the dosing is more important to get an even blood level.
Why does Anavar have distinct cutting properties.
Firstly we need to remember Fat deactivates DHT, And it causes DHT’s conversion into 5alpha-androstane 3alpha,17beta-diol and 5alpha-androstane 3beta,17beta-diol. This isn’t good, Even though in small amounts they can protect against high arterial cholesterol, they have high affinity for the estrogen receptors. The more adipose tissue around the waist, the greater this conversion, more water retention and fat gain inssues.
Now Anti-estrogens cant help with this, they have no affect as their mechanism for action doesn’t prevent DHT’s conversion into these hormones.
However Anavar has a unique way of reducing adipose tissue.
Anavar up-regulates the AR, Anavar also antagonizes the catabolic actions of cortisol, Cortisol as we saw in my last article slows down lipolysis, and decreases free test, Coupled with an up-regulated androgen receptor, less estrogen is able to bind.
Anavar doesn’t easily convert to DHT and so it doesn’t get affected the same way DHT does by adipose tissue, This allows Anavar to be able to take affect, unhindered by deactivation or conversion.
Whats important here, is that the AR gene has different affects in every individual, The AR gene provides instructions for making a protein called an androgen receptor. The AR gene, a DNA segment known as CAG is repeated multiple times, In most people, the number of CAG repeats in the AR gene ranges from fewer than 10 to about 36.
Everyone has varying degrees of whats called Androgen insensitivity syndrome,
And there are over 600 different degrees of mutation, causing a weakness towards Androgenic alopecia, or even prostate cancer.
Anavar upregulates the AR gene, and the Androgen receptor, so if you are genetically predisposed towards Prostate cancers, or Androgenic Alopecia, your more likey to speed up that process, despite it being mildly androgenic itself.
Along with that though comes its unique effect on fat cells.
The increased Sensitivity of androgen receptors causes more nutrients to be directed towards muscle cells and away from fat cells.
It cannot be deactivated by fat cells as we have already seen, and its able to cause lipolysis, the breakdown of triglycerides into Glycerol and Fatty acids.
Anavar Activates a very important enzyme called Hormone sensitive lipase (HSL) and this triggers Noradrenalin and Cyclic adenosine monophosphate into action.
After Anavar is taken, and its active in the system, its up regulation on the androgen receptor and its ability to cause Noradrenalin to bind to adrenoreceptors in fat cells, then Guanine nucleotide proteins cause the enzyme Adenylate cyclase to convert ATP into cAMP. (This is why creatine and Anavar work so well together as creatine increases muscle ATP)
cAMP then binds to the protein kinase A, Then protein kinase A release its catalytic subunit, This subunit phosphorylates (HSL ) it then becomes an active enzyme, called HSL-P, Then finally a 3 step action catalytic action takes place wich causes the breakdown of tryglycerides, they are then released into the blood system and exctreted.
Because the body tries to prevent fat breakdown via negative feedback loop, one way it does this with Anavar is to try and prevent the accumulation of cAMP within cells, Caffeine can be used here as it prevents that, inhibiting phosphodiesterases within the cell. It also can prevent the actions of adenosine, which make it very useful when used along side Anavar at a dose of 60mg -90 mg, pre workout. As too much adenosine can cause the negative feedback on cAMP and reduce its affects even though cAMP is increased.
Anavar dosing is entirely dependent on the size of the individual and the goals, its a much stronger anabolic than many believe, and its affects on fat loss seem to last, as it seems to have the ability to re-set Homeostatis, and allow for much lower bodyfat levels, This could be because its molecules can be contained within the fat cell for long periods, perhaps preventing the re-uptake of fat, or causes noradrenalin to stay bound the the receptor.
Why does anavar cause muscle hardening
Even though it is mildly androgenic, it causes up regulation of the androgen receptor, causing the muscle to take on a much harder appearance, the nitrogen retention that anavar causes, Makes it highly anti-catabolic, so muscle recovery is increased, its activation of certain enzymes burn adipose tissue but also target fat that is in and around muscle bellies, stripping away fat, revealing cuts and stirations within the muscle. The increased vascularity it causes is partly to do with there being less fat, Increased nitrogen retention, and increased blood cell count. Which is why it causes dramatic increases in endurance as well as strength.
Using Creatine with Anavar is important as Anavar can cause ATP to be reduced in its method of burning fat, but it also has the ability to store creatine to a much greater level, And consuming creatine along with Anavar will cause far greater strength increases and fat loss.
As fat is broken down, and nutrients are forced into the muscle, think of the Androgen receptor being like a vacuum, it causes nutrients to be sucked into the muscles, and away from estrogen receptors, Which is another reason why its a great fat loss aid, Anavar is a very potent nutrient repartioner.
All in all Anavar is one of the safest, mildest, but most effective tools for getting that beautiful physique you have dreamed of, Coupled with the right nutrition and training, its results can be nothing short of dramatic.
Just use caution and make sure you have the right PCT and liver protection on hand.
Until next time Russianstar.