How testosterone supplementation shuts you down.

Normally trying to find a definitive answer on anything to do with Shutdown on the forums is like looking for a needle in a haystack, with a who’s who of Bro science “professors” Adding their own inaccurate take on things.

So HERE is exactly how Testosterone supplementation (AAS) Shuts you down.
Abbreviations
LH = Luteinizing hormone
HPTA = Hypothalamic-Pituitary-Testicular Axis
FSH = Follicle stimulating hormone
GnRH = Gonadotropin releasing hormone
When exogenous Testosterone or some steroid derrirative is used, a cascade of actions take place in this order.
 Your Hypothalamus (This is your master gland in your brain) secretes GnRH, then that causes your pituitary gland to secrete secrete LH & FSH, the increase in these hormones causes the testes to stimulate the Leydig cells to produce testosterone (by conversion of cholesterol) testosterone then has the ability to in turn to undergo various metabolic processes that will inhibit GnRH, which in turn inhibits the secretion of LH and FSH, and that brings a halt to natural testosterone production This is the negative feedback loop.
Once testosterone has stopped being produced, it no longer sends this negative signal, and GnRH eventually begins to do its job again.
This is how Homeostatis is maintained in the human body.
The Whole idea of supplementing with steroids is to override the mechanism for negative feedback, We can take huge amounts, and we don’t have to worry about not producing testosterone because we are replacing it with an exogenous source.
The big problem we have is that certain Steroids cause this to a greater degree than others, Estrogenic steroids, or steroids referred to as Wet bulking steroids convert to the hormone Estrogen in larger doses, and this causes greater suppression than an androgen alone.
Here is a quote.
“J Clin Endocrinol Metab. 2001 Jun;86(6):2600-6
Aromatization mediates testosterone’s short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men”
Using something to stop this conversion like Aromasin, Arimadex, Or letrozole, can also decrease the amount of shutdown caused, or speed up the recovery process.
The increased estrogen sends signals that there is too much conversion, why else would a guy have too much estrogen? And your Hypothalamus sends signals that too much estrogen is in your system, so the secretion of LH and FSH is halted, the leydig cells stop producing test, until homeostatis is met, And testosterone has a higher ratio to estrogen, than it has currently.
Some steroids are not as inhibitory of Testosterone production partly because of this reason, Anavar being one, it doesn’t convert to estrogen, and it doesn’t saturate androgen recepetors like say Trenbolone.
Saturation of the Androgen receptor or increased androgen levels in the blood are the main cause of shutdown, And with Steroids like Trenbolone, the effects last a long time because the metabolites linger in the cell and receptor.
 Androgen levels or circulating steroids acting like Testosterone in the system, or being Testosterone itself cause the same manner of actions as outlined above, that process is the negative feedback loop, there is to much circulating testosterone, and that causes the leydig cells to stop producing testosterone, and after a period of inactivity they soften, and shrink.
Prolactin another hormone produced by the pituitary and regulated by the hypothalamus can if elevated decrease Testosterone in men, on cycle its not a problem as you are supplementing with exogenous Testosterone, but.. it can and will lead to side effects both on cycle, and cause problems during recovery in PCT, so suppressing prolactin is a good idea to prevent long lasting problems after a cycle has ended.
Think no libido, enlarged nipples, and leaking nipples, yes your right, prevention is the best cure.
Keeping this in mind when starting a cycle and planning a PCT is vital.
I have made it as simple as I can, it doesn’t need to be complicated,  Restarting the HPTA is much more tricky than causing it to stop working, and recovery can be very lengthy.
Kindest regards RS
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s