Ostarine : Doest it work for PCT?

Osta-sarms
((2R)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
Ostarine.
Mk-2866.
Half life 23.8 hours
Why you need Ostarine (MK2866) in post cycle therapy.
The first question we need to ask, Is Ostarine suppressive? Since I first suggested the use of Ostarine in PCT over 3 years ago not much has changed. Ostarine is suppressive at certain doses but at the right dose it isn’t, it doesn’t allow for full recovery at any dose and this is very important, meaning PCT must be carried on after Ostarine is stopped.
So why use it?
When a steroid cycle is finished the body is extremely catabolic, with increased cortisol and lowered IGF eating away at your new muscle, Ostarine can prevent the immediate catabolism and allow for enough recovery to prevent this initial muscle loss.
Ostarine information.
These were my first experiences with this compound back in 2009.
Ok firstly some of you may have heard of S4 one of the first sarms available, its the most androgenic version, being 1/3 as much as testosterone on androgen receptors in the muscle. To be honest, its the weakest one of the sarms discovered so far, the Ostarine sARM is much better at promoting lean body mass, its more potent, has a longer half life and displays no androgenic effects, its entirely anabolic.
Now the dose you may see in studies that showed good lean mass increases was about 3mg-5mg per person, well before i recently started my myo-t12 log i ran MK-2866 or Ostarine for 40 days, being given a sample from a friend, i dosed it at 10mg  every day for 3 weeks 15mg for 1 week and 20mg for 1 weeks, and these are the results.
Weeks 1-3(10mg) ,mass increases +3lbs, round full muscles, and increased strength, not as hard looking as you get with s4, but very good quality, no bloat, no sides, absaloutley no vision problems, The taste is even better than s4… not hard to achieve mind you considering s4 tastes like urine with an electric current being passed through it, This weight gain was glycogen retention.
Week 4 (15mg),+ 2 lbs in 1 week so 5 lbs overall by this stage, no sides, and no increase or decrease in libido like i had with s4, Ostarine showed no effects on the testis in studies, and i would say its not just hype.
Week 5 + (20mg)2 lbs, i think that 15mg was just as effective, nice lean gains, and some fat loss, though i didnt measure my bmi wich is a shame, i compared s4 with anavar, id say that this is very similar to boldelone, but without any androgen activity, so probably more like primo.
Now i must admit i had blurry vision a few times during week 5, and a funny tingling in my side, and a little bit of a palpitation, (something i never get) after i had been running, so caution is advised, try a lower dose to check the results.
The metabolite M1 wich seems to cause toxicity in S4 doesnt seem to be in S1, As i say sides were only seen when using it at a much higher dose, so far its my favourite sarm, no need for regular doses with the 24 hour half life, One other thing i only really noticed after was that i was tired especialy weeks 4 and 5 most of the time, So 10mg seems to be perfect for gains without sides.
3 Months after this cycle and blood works showing slight suppression and an increase in oestrogen I held on to about 2lbs, but I had a better v taper which showed me that fat loss had been seen, sadly I hadn’t done a BMI check before or after.
My conclusions here
10mg is the correct amount for PCT , more than that will cause suppression, this enough to allow good recovery and keep hold of your gains.
If your cycling Ostarine as a solo cycle or stacked my suggestions will be provided below.
 Ostarine, The benefits as compared to Anabolic steroids.
By now most of you will have heard of sARMS, or selective ANDROGEN RECEPTOR MODULATORS, these new and pioneering supplements bind to the androgen receptor in pretty much the same way anabolic steroids such as Testosterone would, but in a novel and selective way, They exert many of the same anabolic effects that steroids do, but without many of the sides associated with other androgens. The Androgen Receptor plays a vital and significant role in the development and function of sexual organs, skeletal muscle, and bone, as well as other human organs ,When Selective Androgen Receptor Modulators bind to the receptor, they demonstrate powerful anabolic activity in both muscle and bone,(1) This is because they bind to the receptor and change its action in a novel way that is significantly different than typical androgen receptors stimulators such as synthetic androgens and non-synthetic androgens (Steroids) , and so they are able to alter the gene-transcription process in a manner that is tissue specific, in this particular case we are interested in its effects on bone and muscle. Ostarine exerts its effects in a very anabolic way, comparisons have been made with the Anabolic steroid Deca- Durabolin, This is because not only is increased muscle mass seen but it has a very positive effect on joints and bones aswell as nitrogen retention. Now most steroidal androgens convert to DHT or Estrogen so you have the increased chance of DHT related side effects, enlarged prostate for one, and hair loss if your prone, as well as a whole list of other potential DHT related side effects. And Estrogen causes a whole host too, Water retention (Edema), Hypertension (High blood pressure) and the unwelcomed and often hard to treat enlargement of the male breast tissue (Gyno)(2). You also get your own testosterone production shutdown on cycle so a Post cycle therapy protocol is essential to restore correct testosterone levels, even then the ongoing effects of impotence can be seen for many months after full testosterone recovery has been achieved. However those problems along with many others if the steroid of choice is a progestin, can to some degree be eradicated through science, and the development of these new sARMS.
Ostarine (OSTA-SARMS) Doesnt convert to DHT or display any of the side effects by Dihydrotestosterone. In blood tests a slight raise in estrogen levels can be seen, and that might be one of the key factors in its tremendous potential for treating tendon, ligament, and bone injuries or illnesses. It also displays a very anabolic effect on muscle tissue, causing considerbale and easy to maintain gains in muscle over 4-6 weeks, with little to no sides and no real PCT is needed afterwards, just a mild test booster like DAA.
 Another interesting aspect as opposed to your typical steroid is that sARMS remain very hard to detect for Anti-doping agencys as sARMS bypass in effect the well known 4 ring steroid structure, so they are not steroids, but yet sARMS exert many of the same performance enhancing effects that steroids do without the sides (3)
Ostarine, Unleashing its power.
The big question is how do you get the most bang for your buck from Osta-sarms/ MK-2866? Firstly we need to get some facts straight on what it is exactly, its half life and best dose. Ostarine has a half life of 23.8 hours, So a once a day dose is the most effective to get your biggest peak of blood plasma serum levels. Depending on your goals though there are a couple of doses i personaly would recommend.
Anabolic dosing.
Dosing at 24mg-36mg a day gave me my biggest gains in muscle and the best muscle pumps over a 4 week period, going higher than 36mg did not increase the gains in lbm or strength over the same period, for somone weighing 200lbs 24mg is enough to elicit very good anabolism, However for somone weighing above 210lbs, 36mg in experiments i carried out seemed to be a much better dose and offer better general lbm gain, with this dose muscle hardness can be seen to increase after about 6 days.
I suggest front loading Ostarine the first week, Close to double your intended dose, this will speed up the saturation of ostarine in the system and its affect on the androgen receptor.
These very same doses can be used on a cut, with decreased calories to maintain muscle, I highle recommend the use of Osta-sarms in this regard as even in a calorie surplus diet fat loss can be lost at quite a high rate 1-2lb a week, on a cut with added stimulants the loss of viceral fat can be increased exponentialy and muscle tone and hardness will also increase at a rapid rate revealing a ripped and cut physique thats also in a lot better state health wise than if a steroid was used to increase muscle retention during the same period of time.
Bone and tendon repair dosing. One of the outstanding facets of Ostarine is that it doesnt just build muscle, it increases tendon strength, improves the health of the ligaments, increases bone density and increases the rate at wich collagen is turned over. To achieve this a dose of 12mg ed is adequate, and promotes improvement in joint movement that can be seen after just 6-8 days, this dose is very effective for treating injuries like shin splints, and can be used post operation to help maintain muscle and speed up the recovery of the limb, (Bone/Tendon) that has been operated on.
Supplementation while using sARMS.
My favourite supplements wich seem to increase the effectivness of Ostarine are Creatine wich itself increases igf-1 levels,bone density, Lean body mass, and prevents the release of homocysteine thus preventing cardiovascular problems. Zinc and magnesium are a must as both are vital for increase in testosterone levels, androgen receptor sensitivity, and igf-1 levels to remain at a maximal level.
Ostarine in PCT summary.
Remember that you will not fully recover while using Ostarine even at the suggested dose of 10mg a day, which is enough to provide much needed anabolism while allowing recovery, Stopping Ostarine and continuing your pct for a couple of weeks is essential to ensure total recovery from your steroid cycle.
Combining Ostarine with a sERM, and an anti-estrogen , Aromasin or Formestane being my suggestions would be best.
In my next article we will look at the Perfect post cycle therapy with sARM’s
References
1.Selective androgen receptor modulators in preclinical and clinical development.
Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, USA
2.J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):261-6.Prostate cancer risk in testosterone-treated men. Raynaud JP. Université Pierre & Marie Curie, 51 bvd Suchet, Paris 75016, France. 3.Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5.Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 242 L.M. Parks Hall, Columbus, OH 43210, USA
Kindest Regards Russianstar

Methyldiazirinol the new Designer steroid.

Methyldiazirinol.
Synonyms
Triumphalis, Methyl-diaz
Nomenclature
3,3-azo-17a-methyl-5a-androstan-17b-ol
3,3-azo-17α-methyl-5α-androstan-17β-ol
Anabolic/ Androgenic ratio 300/20
Half life 6 hours.
What is Methyldiazirinol?
Methyldiazirinol was first researched  at lederle labs. They then published the results in 1956, and got a patent for the steroid in 1966.
As it has a high anabolic ratio and low androgenic, it would appear to have similar properties to anavar, but act a little more like a stronger version of cynostane in
Julius Vida’s Androgens and Anabolic Agents. In a section detailing “Compounds displaying decreased androgenic activity coupled with increased anabolic activity”,
Promote larger muscle gains with little sides and lots of lethargy.
Its formula is a derivative of diazirinol and may be slightly unstable under heat or over periods of time.
Its structure is very similar to other known and widely used steroids such as Epistane , the difference being instead of Epistane’s episulfide heterocyclic ring in the 2nd and 3rd carbon position, Methyl-diaz has a Diazarine heterocyclic ring.
It is also very similar to Furazabol and Winstrol with again the difference being the 3rd position with Furazabol having a furazane ring, and winstrol having a pyrazole  heterocyclic ring fused at carbon positions 2 and 3.
So Just from that we can see that its likely to be quite dry, and good for cutting, and explosive strength and lean mass.
Receptor bonding is improved in the case of Methyl-diaz with instead of a 3-ketone it contains a stronger nucleophilic heteroatom. The additional Nitrogen atom improves its performance and assimilation.
Being methylated improves its performance, and don’t let its similarities to steroids that don’t add much mass fool you, Dianabol is basically methylated Equipoise, yet its affects are nothing alike.
The same here with Methyl-diaz,  It has similarities with cutting steroids yet this unique 3,3 azo Anabolic designer steroid shows much promise as an out and out mass builder, with very little sides, but masses of nitrogen retention.
.
Cycle length and dosing
This shouldn’t be run for more than 5 weeks, with the best gains coming around weeks 3 and 4. A daily amount of 40-50 mg will offer users a huge amount of increased strength and mass, with gains in the region of 10-15lbs.
Methyl-diaz should be taken with foods containing fat to increase its assimilation by the body.
One can expect gains similar to superdrol, similar sides, but less toxicity. Logs and reviews seem promising. Water retention will be glycogen induced as it does not convert to estrogen. This coumpound will increase nitrogen retention so recovery will be greatly improved. It has good bioavailability with doses of around 20mg 2 x ed. The androgenic affects of this steroid will be reduced and most noticeable via AR regulation, so mainly seen through increased muscle hardness.
It Like Superdol appears to be dry, but to get its full anabolic affects large amounts of glycogen will be needed, so the increased glycogen storage will make it look like you are holding a lot of water.
As the cycle extends into the 4th week or so, these wetter gains will harden up and noticed size increase will be seen.
Toxicity and PCT.
We can expect a negative impact on the liver, blood pressure and good cholesterol, so prevention before and during the cycle by using cycle support supplements would be beneficial.
It appears to be a lot less toxic than other powerful mass building steroids.
Methyl-diaz doesn’t convert to DHT, oestrogen, or interact with progestin, it has its own direct affects on the AR receptor in the muscle, and therefore is unlikely to cause any kind of hair loss
Kindest regards Russianstar

RUSSIANSTAR’s :GHRP-6 information.

GHRP-6 : What is it and what does it do?
Firstly to get things clear GHRP-6 is a peptide a Growth Hormone Releasing hexapeptide , its a 28 amino acid peptide, and it works by signaling to the pitruitary gland to begin secreting Growth Hormone.

2SMolecular Formula C46H56N12O6 Molecular Weight 873.01 CAS Registry Number 87616

6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenyl-propanoyl]amino]hexanamide

GHRP-6 lackS opioid activity, but you get a huge pulse, (dose dependant) in your own GH levels, and you get the effects of the increased IGF-1 secreted by the liver. Now both the increased GH and IGF-1 are highly desirable for atheletes, bodybuilders and those looking to improve their own physique. Now you may have heard many tell you that when they take GHRP-6 the best GHRP i have used, that they get a huge and very intense increase in appetite, about 20 mins after the initial injection, Well this is caused by the GHRP-6 antagonising the peptide Ghrelin, it mimicks it, but actualy fights against it causing the signal for gastric emptying and hunger. Ghrelin is what many believes causes obesity, and insulin resistance amongst other things, and i believe this is one way by wich GHRP-6 may help reduce fat, by fighting against it in effect … but, and there is always a but, if you take more than 150mcg the effects of the gastric emptying can be so strong that you may have the urge to severely stuff yourself with foods, so if your on a bulk this is a great side effect, and considering the price its a very good one, so on a bulk i rate this as the number one aid in increasing appetite, as you get very good anabolic effect too and increased strength

Russianstar’s personal experiences.
 Well personaly i used 150mcg injected directly into the joints or areas that ive had any niggling injuries, the localised effect it has on collagen growth is nothing short of astounding, and i have personaly recovered from a full pectoral tendon tear, where the tendon ripped right of the humerous bone, its now in even better shape than it was prior to the injury, and 5g of the GHRP-6 will last ages when used accordingly, even at this dose fat loss is noticeable and the anabolic effects of increased muscle size and strength can be seen. One of the other uses is to kick start your own GH after a cycle, a dose of 200-500mcg 2 x a day is sufficient to start your own GH, however it does not mean to say your own GH levels will be where they were before you carried out your cycle, this is user dependant, but it will certainly be a very usefull addition, and a usefull addition to any hormonal cycles PCT as the increased igf-1 levels it brings will greatly increase the chances of you holding on to any muscle you have gained. Another thing i noticed was the improvement in my immune system, and my well being, this is partly because of the effect GHRP-6 can have on the increase again in IGF-1 wich plays an important role in the healthy function of your immune response. It also has a healthy protective effect on neurons and on the CNS (central nervous system).
Other benefits.
In one study i saw recently it was shown that GHRP-6 GHRP-6 has a protective effect on the liver that seems to be mediated by IGF-I, TNF-alpha, and nitric oxide. Data also suggest that the anti-inflammatory effect of GHRP-6 in the liver is exerted on nonparenchymal cells, So again for pct this may prove an invaluable asset.
As for peptides they are fairly new as compared to other anabolics, but they i feel are far better, and have way more potential, just how much remains to be seen. Just remember with GHRP-6 not to eat carbs or fats 50 mins each side of the dose so as not to interfere with the gh pulse it will cause, and 250mcg 3 x a day is the best dose i found to avoid overly mimicking ghrelin and still cause a large amount of muscle gain, tissue repair and fat loss.
As a peptide GHRP-6 is one of the easiest and most affective to use. A daily dose of just 300mcg split up into 3 doses will see a marked improvement in skin tone within 3 weeks, apart from all its other benefits, as an Anti-aging peptide this tops my list of all the injectable GHRP-s
Kindest regards Russianstar.

ATD a potent anti-oestrogen

3,17-dioxo-etiochol-1,4,6-triene
1,4,6-Androstatrien-3,17-dione
1,4,6 etiollochan-dione
Known as: ATD
Half life : 48 hours
Molar mass: 282
What is ATD?
1,4,6-Androstatrien-3,17-dione (ATD) is a potent irreversible A.I that inhibits estrogen biosynthesis by permanently binding and inactivating the Aromatase enzyme in the adipose tissue, (Fat cells) and in the surrounding peripheral tissue.
It can be used on cycle and during PCT to reduce estrogen and help recover natural testosterone production.
ATD has 90% androgenic activity in muscle tissue but only 10% androgenic activity in the hypothalamus. What this means is it helps you hold onto muscle and it also means that ATD blocks the Androgen-Negative-Feed-Back-Loop and aids in decreasing estrogen production while increasing natural testosterone production. Used on cycle it should help reduce shutdown, and prevent estrogen related sides.
How does it work?
There are two main negative feedback loops that we need to consider in PCT. The first is elevated estrogen levels from aromatase activity that will act on the hypothalamus to decrease GnRH production. The second is that elevated androgen levels stimulate androgen receptors in the hypothalamus causing decreased GnRH production. Decreased GnRH leads to reduced LH and FSH production, both of which are directly involved in testosterone production.
ATD combats this in a very interesting way.
ATD works for androgen activity the same way that Serm’s like Nolvadex block estrogen in breast tissue, but allows estrogen to have positive effects in other organs and tissues such as the liver and bone. ATD blocks androgens in the hypothalamus, but allows it to be active in the muscle, By doing this it increases GnRH production, increasing LH and FSH leading to increased testosterone.
ATD also lowers estrogen and is therefore able to increase GnRH from that angle also.
This is how it tricks your body into producing more testosterone.
How can it be used?
Obviously it can be used in PCT, but it has therapeutic affects on cycle, first it only has Anti-androgen affects in the hypothalamus, this means that along with it not interfering with any positive affects from AAS, it also means less shutdown as the androgenic or estrogenic affects of steroids are unable to cause shutdown in the same way as they would without ATD.
As it prevents estrogen and androgens from shutting down GnRH production, less HTPA shutdown takes place, and so recovery after stopping the steroid cycle is much easier.
What does is affective?
25mg a day of ATD on cycle will prevent a large measure of shutdown, obviously depending on what AAS are being used, higher amounts than this can cause severe joint pains and dryness..
During PCT you will notice a surge in libido and then libido drop off, so I suggest starting at 50mg a day, then tapering off this allows for estrogen and androgen levels to return to homeostatis, and it will also prevent estrogen or androgen rebound, prevent Acne and estrogen related rebound sides.
Points of interest.
ATD will give a positive sample as its metabolites are similar to that of the vetinary steroid Equipoise, so please keep this in mind.
Kindest regards Russianstar.