Russianstar experiences with CJC-1295 DAC

Russianstar ” EXPERIENCES WITH CJC-1295 DAC”

Firstly lets explain what the peptide CJC-1295 DAC is.

Molecular Formula: C152H252N44O42

Molecular Weight: 3368.7

Sequence of CJC1295 (modified) without DAC:

H-Tyr-(D)Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-

Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

CJC-1295 is a GHRH (the 44-amino acid long version) with 15 aminos removed, thus a total of 29 amino acids, and bound to DAC it is also called Drug Affinity Complex, and CJC-1295 is often referred to as GHRH with Drug Affinity Complex, this essentialy lengthens its life span.
This is how its life is lengthened.
The modification of growth hormone releasing factor with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 2 create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By utilising the Drug Affinity Complex technology to GRF, the peptide selectively binds to circulating albumin after subcutaneous administration, thus prolonging its half-life.
As you may notice its basicly semorelin with 15 aminos removed. This was because semorelin degrades too rapidly to really make it a viable cost efficient option.
So they bonded it with an attached 3-maleimidopropionic acid (MPA) unit, which results in binding to albumin after exogenous injection into blood plasma, and creates a far longer half life, this is the DAC, or druf affinity complex i made referance to earlier.
Now it works by this action as its a GHRH, or growth hormone releasing hormone, In the healthy human body, large amounts of growth hormone are stored in the pituitary. The cells within the pituitary release growth hormone in response to signalling by GHRH (Growth Hormone Releasing Hormone) Then the peptide Ghrelin is (of which GHRPs – Growth Hormone Releasing Peptides – are mimetics), inhibited from releasing these stores by Somatostatin. GHRH and Ghrelin act on different populations of somatotropes (GH releasing cells). GHRP and Ghrelin increase the number of somatotropes releasing GH but not the amount released by each cell.
GHRH affects both the number of secreting cells and – moreso – the amount they are actualy able to secrete. GHRH and Ghrelin are released in specific patterns that vary depending on what the person involved is doing, or has been doing post-exercise. Now CJC-1295 DAC has been proven to stimulate slow wave sleep, and this is the period of sleep when most of your bodys repairing work takes place on muscles and tissues etc.
Now most people can and will make GH in their own pituitary gland, but not everyone can release it in the amounts needed, so from a medicinal point CJC-1295 DAC can be very beneficial.

Now for its benefits to reach full potential, somatostatin needs to be inhibited because we have just seen it inhibits gh release, so by using a compound known as an Acetylcholineesterase inhibitor, now Acetylcholineesterase inhibits acetylcholine, and Acetylcholine inhibits somatostatin, so we want Acetylcholine in abundance, so by using an Acetylcholineesterase inhibitor, we allow acetylcholine to inhibit somatostatin, so increasing the amount of gh released when using CJC-1295DAC. Got it? Ok re read that last passage.
The best of these Acetylcholineesterase inhibitors and there are lots like..
Physostigmine
Neostigmine
Pyridostigmine
Ambenonium
Demarcarium
Rivastigmine
Phenanthrene derivatives
Galantamine
Piperidines
Donepezil, also known as E2020
Tacrine, also known as tetrahydroaminoacridine (THA’)
Edrophonium
Huperzine A
Ladostigil,
Of the ones ive tried Huperzine A is the very best, and fairly cheap, now by adding ECGCs from green tea, as these ECGCs will transport the huperzine better so finding the receptor it needs the effects are even stronger on inhbiting the acetylcholineesterase.
Otherwise a really good one i used recently was Horny goat weed, its the only one i know that actualy increases acetylcholine as it inhibits the enzyme acetylcholinesterase.
Personally i rate this as my favourite peptide, you get nearly a constant surge in gh especialy if you add in say huperzine A, you get all the benefits of hgh, improved body composition, anabolic effects, injury recovery, improved skin, the full works, and at a very good price, far cheaper than real gh.
I have found that between 2000mcg -5000mcg a week has given me great results, increased bodymass over a 15 week period of nearly 9lbs, thats not weight gained, thats pure muscle and fat loss, You get all the same benefits of hgh, but you get them constantly, not just in one or 2 surges when you use the injections.
Now i would use this in fat deposits as i noticed a reduction when i did so quite quickly, and directly into a muscle with this is quite painfull to say the least, so thats a no no from me.
Expect to see results after just a couple of weeks, and the large amounts of igf-1 released will really add some muscle when incoorporated with a good diet and training regime.

There are no sides ive seen with cjc just positive ones except for the amazingly strong head rush you get about 20 mins after the injection, this a tell tale sign as to wether or not you have the real thing.
Remember the pulses are not as big as when you use GHRP-6, but rather its a continuous elevation of gh secretion peaking about 2 hours after the injection and staying elevated for 14 days. I use it 4 times a week in 500mcg doses and find this to be perfect for maintaining muscle when unable to train, say because of injury, and improving skin tone and health.
3500mcg is a far more anabolic dose and muscle mass will be noticeably improved after 4 weeks, and the skin will start to take on that shredded ultra thin look that gh users get before competitions.
All the benefits of real GH, less injections, less sides, a lot less money…. need i say more.

I hope you have found this information helpfull, i feel its one of the very best peptides if not the best.

Russianstars peptide rating 9/10

Kind regards RS

Russianstar experiences with Ostarine Updated

RUSSIANSTAR “EXPERIENCES WITH MK-2866…(OSTA-SARMS) Ostarine.sARM S1
sARMS s1

((2R)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

Ostarine.

Mk-2866.

Half life 23.8 hours

Ok firstly some of you may have heard of S4 one of the first sarms available, its the most androgenic version, being 1/3 as much as testosterone on androgen receptors in the muscle.
To be honest, its the weakest one of the sarms discovered so far, the Ostarine sARM is much better at promoting lean body mass, its more potent, has a longer half life and displays no androgenic effects, its entirely anabolic.

Now the dose you may see in studies that showed good lean mass increases was about 3mg-5mg per person, well before i recently started my myo-t12 log i ran MK-2866 or Ostarine for 40 days, being given a sample from a friend, i dosed it at 10mg for 3 weeks 15mg for 1 week and 20mg for 1 weeks, and these are the results.

Weeks 1-3(10mg) ,mass increases +3lbs, round full muscles, and increased strength, not as hard looking as you get with s4, but very good quality, no bloat, no sides, absaloutley no vision problems, The taste is even better than s4… not hard to achieve mind you considering s4 tastes like urine with an electric current being passed through it.

Week 4 (15mg),+ 2 lbs in 1 week so 5 lbs overall by this stage, no sides, and no increase or decrease in libido like i had with s4, Ostarine showed no effects on the testis in studies, and i would say its not just hype.

Week 5 + (20mg)2 lbs, i think that 15mg was just as effective, nice lean gains, and some fat loss, though i didnt measure my bmi wich is a shame, i compared s4 with anavar, id say that this is very similar to boldelone, but without any androgen activity, so probably more like primo.

(I later found front loading and splitting a higher dose was far more effective for mass accrual)

Now i must admit i had blurry vision a few times during week 5, and a funny tingling in my side, and a little bit of a palpitation, (something i never get) after i had been running, so caution is advised, try a lower dose to check the results.

The metabolite M1 wich seems to cause toxicity in S4 doesnt seem to be in S1, As i say sides were only seen when using it at a much higher dose, so far its my favourite sarm, no need for regular doses with the 24 hour half life, One other thing i only really noticed after was that i was tired especialy weeks 4 and 5 most of the time, So 10mg seems to be perfect for gains without sides.

I loved the fat loss and hardening of S4, but prefer the mass of S1, As a pct aid this gets the thumbs up, a nice cycle of this cjc, and ghrp-6 might just be the ticket.
One other point, i had an aching wrist, and that went during the second week, s1 was intended for people with muscle wasting diseases, but it holds promise for those with bone diseases too.

Hope you all enjoyed my experiences, il post my S4 experiences soon, now get hold of some of this when you can, and log it so everyone can see your results.

Ostarine unleashing its anabolic power.

Ostarine/ MK-2866 Unleashing its anabolic power.

Wether its the ripped physiques of top athletes or the huge vascular muscles the Pro-Bodybuilders have developed, All of us are aspiring to something, even perhaps maintaining some degree of strength or muscularity during or following injury and on the way back to recovery, or we might just want to stay in shape.
The range of supplement aids we could use to help us reach our goals is ever expanding, ever changing, But one NEW supplement recently available online has already taken the bodybuilding and fitness world by storm, so what is it? And why is it so effective?

Ostarine, The benefits as compared to Anabolic steroids.

By now most of you will have heard of sARMS, or selective ANDROGEN RECEPTOR MODULATORS, these new and pioneering supplements bind to the androgen receptor in pretty much the same way anabolic steroids such as Testosterone would, but in a novel and selective way, They exert many of the same anabolic effects that steroids do, but without many of the sides associated with other androgens. The Androgen Receptor plays a vital and significant role in the development and function of sexual organs, skeletal muscle, and bone, as well as other human organs ,When Selective Androgen Receptor Modulators bind to the receptor, they demonstrate powerful anabolic activity in both muscle and bone,(1) This is because they bind to the receptor and change its action in a novel way that is significantly different than typical androgen receptors stimulators such as synthetic androgens and non-synthetic androgens (Steroids) , and so they are able to alter the gene-transcription process in a manner that is tissue specific, in this particular case we are interested in its effects on bone and muscle.
Ostarine exerts its effects in a very anabolic way, comparisons have been made with the Anabolic steroid Deca- Durabolin, This is because not only is increased muscle mass seen but it has a very positive effect on joints and bones aswell as nitrogen retention.
Now most steroidal androgens convert to DHT or Estrogen so you have the increased chance of DHT related side effects, enlarged prostate for one, and hair loss if your prone, as well as a whole list of other potential DHT related side effects. And Estrogen causes a whole host too, Water retention (Edema), Hypertension (High blood pressure) and the unwelcomed and often hard to treat enlargement of the male breast tissue (Gyno)(2). You also get your own testosterone production shutdown on cycle so a Post cycle therapy protocol is essential to restore correct testosterone levels, even then the ongoing effects of impotence can be seen for many months after full testosterone recovery has been achieved.
However those problems along with many others if the steroid of choice is a progestin, can to some degree be eradicated through science, and the development of these new sARMS.

Ostarine (OSTA-SARMS) Doesnt convert to DHT or display any of the side effects by Dihydrotestosterone. In blood tests a slight raise in estrogen levels can be seen, and that might be one of the key factors in its tremendous potential for treating tendon, ligament, and bone injuries or illnesses. It also displays a very anabolic effect on muscle tissue, causing considerbale and easy to maintain gains in muscle over 4-6 weeks, with little to no sides and no PCT needed afterwards.
Another interesting aspect as opposed to your typical steroid is that sARMS remain very hard to detect for Anti-doping agencys as sARMS bypass in effect the well known 4 ring
steroid structure, so they are not steroids, but yet sARMS exert many of the same performance enhancing effects that steroids do without the sides (3)

Ostarine, Unleashing its power.

The big question is how do you get the most bang for your buck from Osta-sarms/ MK-2866?
Firstly we need to get some facts straight on what it is exactly, its half life and best dose.
Ostarine has a half life of 23.8 hours, So a once a day dose is the most effective to get your biggest peak of blood plasma serum levels. Depending on your goals though there are a couple of doses i personaly would recommend.

Anabolic dosing.

Dosing at 24mg-36mg a day gave me my biggest gains in muscle and the best muscle pumps over a 4 week period, going higher than 36mg did not increase the gains in lbm or strength over the same period, for somone weighing 200lbs 24mg is enough to elicit very good anabolism, However for somone weighing above 210lbs, 36mg in experiments i carried out seemed to be a much better dose, and in general lbm gain, and muscle hardness can be seen to increase after about 6 days.

These very same doses can be used on a cut, with decreased calories to maintain muscle, I highle recommend the use of Osta-sarms in this regard as even in a calorie surplus diet fat loss can be lost at quite a high rate 1-2lb a week, on a cut with added stimulants the loss of viceral fat can be increased exponentialy and muscle tone and hardness will also increase at a rapid rate revealing a ripped and cut physique thats also in a lot better state health wise than if a steroid was used to increase muscle retention during the same period of time.

Bone and tendon repair dosing.

One of the outstanding facets of Ostarine is that it doesnt just build muscle, it increases tendon strength, improves the health of the ligaments, increases bone density and increases the rate at wich collagen is turned over. To achieve this a dose of 12mg ed is adequate, and promotes improvement in joint movement that can be seen after just 6-8 days, this dose is very effective for treating injuries like shin splints, and can be used post operation to help maintain muscle and speed up the recovery of the limb, (Bone/Tendon) that has been operated on.

Supplementation while using sARMS.

My favourite supplements wich seem to increase the effectivness of Ostarine are Creatine wich itself increases igf-1 levels,bone density, Lean body mass, and prevents the release of homocysteine thus preventing cardiovascular problems. Zinc and magnesium are a must as both are vital for increase in testosterone levels, androgen receptor sensitivity, and igf-1 levels to remain at a maximal level.

The future of bodybuilding is here right now, We have possibly the biggest break through in modern muscle building science at our very finger tips, its not only a powerful lean muscle building catalyst, but it has near unlimited potential in the prevention of injuries ( something all bodybuilders are prone too) And the recovery from injury that can sometimes take a long period. Ostarine has arrived, Its POTENT, ANABOLIC, AND EFFECTIVE… But are YOU ready for it?

References

1.Selective androgen receptor modulators in preclinical and clinical development.

Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT.
Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, USA

2.J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):261-6.Prostate cancer risk in testosterone-treated men.
Raynaud JP.
Université Pierre & Marie Curie, 51 bvd Suchet, Paris 75016, France.
3.Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5.Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.
Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT.
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 242 L.M. Parks Hall, Columbus, OH 43210, USA

Written by Russianstar

Russianstar experiences with sARMS S4

RUSSIANSTAR “EXPERIENCES WITH sARM S4 Acetamidoxolutamide
Written by Russianstar, this info is copyrited.

S4 Is a sARM

Formula C19H18F3N3O6
Mol. mass 441.357 g/mol

chemical name: S-3-(4-acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-
trifluoromethylpheanyl)propionamide.

Andarine

I have actualy used Andarine a couple of times, just so everyone knows exactly what Anadrine (s4) is, here is some info on it.
It is a sarm, a selective androgen receptor modulator, of the sarms currently being studied (s4 studies have been stopped due to the toxic effects of the metabolite M1 that binds to the occular receptor, the heart and other organs) s4 is the weakest in anabolic activity, but one of the most androgenic, being 1/3 as strong as testosterone at binding to the androgen receptor.
Dont look at the info on wikipedia half the stuff is wrong, this does not reduce the size of the prostate. It will over time enlarge it, and it does cause suppression, though its mild.
The best part of s4 is the fact that it causes a drying out of the muscle and the skin surrounding it, and in turn it binds very well to the androgen muscle receptors, Hardening and sharpening the muscle, so towards the end of a cycle it would proove to be very effective.
SARMS s4 causes significant weight loss by binding to the androgen receptors it allows for fat to be oxidised, and this also makes it very usefull.
Recovery from an s4 cycle is pretty straight foward, id reccomend Hcgenerate by needtobuildmuscle as it stimulates the leydig cells to function at an optimal level.

So despite the mild suppression s4 is a very usefull sarm, or rather i should say was.. i wont ever use it again as the problems caused by the metabolite m1 could prove to change our own DNA through the gene transcription process actualy causing irreversable changes to our own DNA, as the DNA transcribed into our RNA may replicate, and be permanent, therefore the possible macular degeneration could continue or even be permanent… time will give us the answer.
As a comparison i would compare s4 to winstrol but without the binding to the scalp, or any real changes to our cholesterol.
Interestingly i asked for one client to use s4 to help with gyno, as its androgenic., as it binds to the androgen receptors it seemed feesable, and dht being a potent anti-estrogen, it seemed a logical conclusion to draw.
However no changes were seen in this trial using 30mg daily. But that trial will continue.

Russians cycle results.

I used 50mg the first week, 60mg the second, 70 the third, 100 the fourth, 125 the 5th week, here are my results.

Week 1. 50mg s4, no gains, noticed increase in energy, no sides.

Week 2. 60mg, increased strength in the gym, great sens of well being, increased libido, no sides.

Week 3. 70mg +1lb in weight, signs of fat loss, and muscle hardening, yellow tint to my eyesight, problems adjusting to light and dark.

Week 4. 100mg +1lb, big strength and endurance increase, no night vision, very sore eyes, black circles under my eyes.

Week 5. 125mg +1.5lb, severe muscle hardening, looks like im on winny and anavar in the 5th week of a cycle, permanent yellow tint in the day to my eye sight, no night vision, tremendous muscle endurance, increased strength, but sides far out weigh the benefits.

SUMMARY

Eye sight returned to normal after i finished the cycle within 4 days, no changes to blood pressure or cholesterol.
Muscle gained was a very lean 3.5lbs, ive kep them ever since, and the muscle hardening has lasted also.
It held remarkable promise, but im put off from using it again after its studies were stopped, and s1 seems far safer.

If you were to run this id use it 5 days on 2 off at 50-70mg, this should negate any sides, its short half life 2.6 hours should make it perfect to use as a pulse, 3 times a week 2 hours before training should give excellent strength and hardening results.

Russianstars sarm rating 7/10 because of toxicity issues.

Use carnatine eye drops while on cycle as they protect the occular receptor, and NA-C to protect the liver.
I Prefer most of all to use epithalon to protect against any damage.

Kind regards RS