Titan 12% dht gel (faq)

What is Titan?

Its a clear rapidly absorbed liquid containing DHT

How much DHT is in Titan?

Per serving you get 12.5mg of Titan, 2 servings a day, the bottle will last you 2 months.

1500mg of DHT per bottle.

Who can use it?

If you want a granite like appearance the pros get, you can use titan for that as DHT drys you out and reduces estrogen. it also lowers SHGB without putting strain on your liver.

If you are suffering with issues caused by DECA or TREN , then the so called Deca dick can be prevented by the use of 3 applications to the shoulders and chest per day of titan.

If you have a penis you are not happy with, 2 x a day applications of Titan can grow your penis, both in length and girth.

If you are dieting, Titan can help reduce fat and dry you out, 3 x applications per day will reduce GYNO when applied to the nipple area.

If you are a Transgender, or in the process of a sex change, Titan will save you huge amounts of money and help you become more masculine in record time.

Anyone can use Titan, long term use has shown to be safe.

 

How does it look?

Titan is a clear gel, we send it stealth so it is very discreet.

Where do you ship too?

We ship worldwide, signed and tracked so you can have faith you will receive titan.

How do I know it will work?

Lots of studies show DHT gel will work in the areas discussed above.

Why should I use TITAN?

Titan is patent pending and is the STRONGEST DHT gel on the market, specially designed to be safe to use on your penis area,

What payments do you accept?

Western union,  paypal, and soon bitcoin.

Is it legal?

Depending on your country as laws vary.

Where can I buy it?

Click here!

WWW.RUSSIANSTARPEPTIDES.COM

for a limited period use this code titan15 all small case for a further 15% off TITAN.

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TITAN IS DHT NOT TESTOSTERONE, WHAT IS DHT?

Ok guys are there is some confusion here.

Testosterone converts into two very distinct hormones.
Estrogen
And DHT OR DIHYDROTESTOSTERONE, OR 5a-dihydrotestosterone.

Testosterone converts into DHT via 5a reductase.

Other names for DHT are..

Androstolone, stanolone, anabolex, anaprotin, andractim, androlone, gelovit, pseomax, stanaprl, neoprol, adactrim, testexdht, and of course the first real copy and strongest formula on the market TITAN.

DHT is used in science and in medicine as an androgen, it cannot via any pathway convert into Testosterone.
It cannot aromatize, and so therefore it cannot cause any of the sides associated with Testosterone conversion into estrogen.

DHT has 33 times the affinity to Androgen receptors than Testosterone.
If a person is born with congenital 5-a reductase deficiency , you wont have the predominant characteristics of a fully developed man, and some of these are..
Gyno , small penis, high balls, low testosterone, a round face, weak features, no body hair, small chin, saggy skin.
They may have normal testosterone levels, but without DHT they do not develop normally.

DHT binds stronger to receptors than estrogen, which is why it can be used instead of aromasin, arimidex or letro to reduce estrogen without lowering igf. Even though aromasin elevates igf , it does not to the same degree dht does.

DHT can be used to prevent gyno, and it has been used to treat gyno caused by a lack of dht in many clinical studies. Masteron was used as an injectable because of its ability to bind to the androgen receptor and reduce GYNO, it also can lower water retention on cycle caused by estrogen and prolactin.
DHT does this to a far greater degree, it also reduces SHBG far more than provirion, winny or masteron.

The other way DHT works is to increase penis length, by binding to the receptors in the penis it increases length, health, and girth of the erection and flaccid penis. Studies have shown DHT to be the only successful way to treat a small penis or micro penis. And its been prescribed for this with an inflated price tag.

TITAN is DHT nothing else, with a unique carrier its able to penetrate and bind to the androgen receptor, it lowers estrogen, dries up the user, and increases mental clarity. Over time prolonged use increases the penis length and makes the user more masculine.

Why would you want to lower your estrogen, or use a synthetic estrogen when you can use TITAN?

Over use can interfere with testosterone production and lower its output, but through topical application this is rarely an issue.

Kindest regards R.S

 

BUY TITAN HERE

 

12% DHT GEL

 

WWW.RUSSIANSTARPEPTIDES.COM

Steves log for TITAN 12%dht gel

This guy wrote a review on my site and I was inspired by this guy, very honest and deliberate , a guy struggling with feelings of insecurity. 3 months after first buying Titan, the guy has seen changes, and even more importantly felt them. He feels more confident and that’s a continued journey to where he wants to be.

http://forum.bodybuilding.com/showthread.php?t=171429491&p=1442386991#post1442386991

Here are a list of reviews from the website for titan so far.

rob (uk) – 12/03/2016:

Been using this for 12 weeks, had it checked first, its supposed to be 12% dht but its actually stronger, was 14%. And real DHT so that was good, also ive gained 1.3 cm in length already. I will be running this for at least a year.
Thank you Russianstar for bringing out an amazing product, customer for life here. Don’t like the DMSO smell though haha. Best thing is flaccid length is up nearly 0.7 inches!! And balls look swollen, erections seem harder but that might be my imagination. I will let you all know how it goes!
RUssianstar – 13/03/2016:

I am glad to hear of your results , I’m sure there will be a lot more results before long.
Thank you, R.s

5

    out of 5

DR WHOO

21/03/2016

    :
      I wont say my name as I am a little embarrassed , but I want to share my experiences. I have micro penis, and the nhs wont help me as they say I’m of sound mind, what a joke, anyway in November 2015 I came across this. Ive been using it 3 x a day every day, nhs told me it would need 3 years of dht application so I’m not expecting miracles.

 

      4 months in I have increased in length 0.5 inches which for me is massive, I’m using a pump now as I was too small to use it earlier and every day it feels stronger and longer, this may well change my entire life. if it does you deserve the nobel bro! Thank you hope you don’t mind me posting this up you can moderate it if you like.

 

    Thanks again DR WHOO

4 out of 5

Mr big – 08/04/2016:Well I have one complaint the smell, but apart from that ive been using this since December and I’m much thicker in girth which is what I wanted, it takes time and every day application but the stuff works!! Bravo!!

 

5 out of 5

Cigarguy19 – 28/04/2016:

I can’t give a full review yet, as I just tried it today. I was waiting by the mailbox like a hawk. I did not notice a strong smell. It must be from your new batch. It’s more of a liquid than a cream or gel. That makes it a little difficult to measure. Other than that, I’m glad you made this. I’d love to know where Rob had it tested. Here’s to bigger and better things.

levi.filimanov – 02/05/2016:

Thank you so much bro, I can message rob on here and find out for you.

 

 

5 out of 5

Cigarguy19 – 02/05/2016:
Like I said, the smell isn’t as strong as I’ve read about but it is kind of a metal smell. Dries out the area in which it is applied. However, dryness can be fixed. My first comment is still waiting approval after a few days. Hope you’re still there.

levi.filimanov – 02/05/2016:

Sorry bro didn’t see the comment come in, thank you for your honest review, maybe I can work on the dryness with the next batch.

 

5 out of 5

bango – 02/05/2016:

I have using this for 12 weeks and this week I’m seeing a change , I know dmso can big vasolidation , (right word?) but this is different the muscle is getting thicker.
My cousin ordered this too and she is using it because she having a sex to change into men. She say it save her so much euro because other gel is weak and expensive.
Thank you great Titan product,!!

5 out of 5

Amyra– 06/05/2016:

Thank you from Dubai!!!

 

5 out of 5

LUIS – 06/05/2016:

This is great, good customer service and very helpful.
I send this all the way from brazil!

 

5 out of 5

Cigarguy19 – 12/05/2016:

Wow Levi. I’m impressed. I’m starting to notice a bit of growth after 2 weeks. Thank you for making such a high percentage at a decent price. Bango is correct about the other product; low percentage and very high cost. Gives a nice tingle when applied too, lol. Must be the vasodialation. I should probably get my testosterone level checked to make sure it’s not getting too high. Thanks again.

 

5 out of 5

Steve – 16/05/2016:

Hi my name is steve and this has changed my life, no lie.. you deserve a nobel prize bro
I am logging this on bodybuilding.com amazing stuff.
http://forum.bodybuilding.com/showthread.php?t=171429491&p=1442386991#post1442386991

  1. Please all follow me, I’m just an average joe, no affiliations.
    Huge thanks from Canada.

     

    Please follow steves log I hope he keeps it updated, the sale for Titan is still going on. If you post an honest review on the website by clicking the star rating below Titan then email me your review at orders@russianstarpeptides.com ,  your next order I will give you a free bottle of titan when you buy 2 bottles!!! Buy 2 get 1 free just for posting your review.

We need to spread the word and help other guys like steve who struggle with insecurities , and we all need your support to do this.

Thank you R.s

 

Ostarine : Doest it work for PCT?

Osta-sarms
((2R)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
Ostarine.
Mk-2866.
Half life 23.8 hours
Why you need Ostarine (MK2866) in post cycle therapy.
The first question we need to ask, Is Ostarine suppressive? Since I first suggested the use of Ostarine in PCT over 3 years ago not much has changed. Ostarine is suppressive at certain doses but at the right dose it isn’t, it doesn’t allow for full recovery at any dose and this is very important, meaning PCT must be carried on after Ostarine is stopped.
So why use it?
When a steroid cycle is finished the body is extremely catabolic, with increased cortisol and lowered IGF eating away at your new muscle, Ostarine can prevent the immediate catabolism and allow for enough recovery to prevent this initial muscle loss.
Ostarine information.
These were my first experiences with this compound back in 2009.
Ok firstly some of you may have heard of S4 one of the first sarms available, its the most androgenic version, being 1/3 as much as testosterone on androgen receptors in the muscle. To be honest, its the weakest one of the sarms discovered so far, the Ostarine sARM is much better at promoting lean body mass, its more potent, has a longer half life and displays no androgenic effects, its entirely anabolic.
Now the dose you may see in studies that showed good lean mass increases was about 3mg-5mg per person, well before i recently started my myo-t12 log i ran MK-2866 or Ostarine for 40 days, being given a sample from a friend, i dosed it at 10mg  every day for 3 weeks 15mg for 1 week and 20mg for 1 weeks, and these are the results.
Weeks 1-3(10mg) ,mass increases +3lbs, round full muscles, and increased strength, not as hard looking as you get with s4, but very good quality, no bloat, no sides, absaloutley no vision problems, The taste is even better than s4… not hard to achieve mind you considering s4 tastes like urine with an electric current being passed through it, This weight gain was glycogen retention.
Week 4 (15mg),+ 2 lbs in 1 week so 5 lbs overall by this stage, no sides, and no increase or decrease in libido like i had with s4, Ostarine showed no effects on the testis in studies, and i would say its not just hype.
Week 5 + (20mg)2 lbs, i think that 15mg was just as effective, nice lean gains, and some fat loss, though i didnt measure my bmi wich is a shame, i compared s4 with anavar, id say that this is very similar to boldelone, but without any androgen activity, so probably more like primo.
Now i must admit i had blurry vision a few times during week 5, and a funny tingling in my side, and a little bit of a palpitation, (something i never get) after i had been running, so caution is advised, try a lower dose to check the results.
The metabolite M1 wich seems to cause toxicity in S4 doesnt seem to be in S1, As i say sides were only seen when using it at a much higher dose, so far its my favourite sarm, no need for regular doses with the 24 hour half life, One other thing i only really noticed after was that i was tired especialy weeks 4 and 5 most of the time, So 10mg seems to be perfect for gains without sides.
3 Months after this cycle and blood works showing slight suppression and an increase in oestrogen I held on to about 2lbs, but I had a better v taper which showed me that fat loss had been seen, sadly I hadn’t done a BMI check before or after.
My conclusions here
10mg is the correct amount for PCT , more than that will cause suppression, this enough to allow good recovery and keep hold of your gains.
If your cycling Ostarine as a solo cycle or stacked my suggestions will be provided below.
 Ostarine, The benefits as compared to Anabolic steroids.
By now most of you will have heard of sARMS, or selective ANDROGEN RECEPTOR MODULATORS, these new and pioneering supplements bind to the androgen receptor in pretty much the same way anabolic steroids such as Testosterone would, but in a novel and selective way, They exert many of the same anabolic effects that steroids do, but without many of the sides associated with other androgens. The Androgen Receptor plays a vital and significant role in the development and function of sexual organs, skeletal muscle, and bone, as well as other human organs ,When Selective Androgen Receptor Modulators bind to the receptor, they demonstrate powerful anabolic activity in both muscle and bone,(1) This is because they bind to the receptor and change its action in a novel way that is significantly different than typical androgen receptors stimulators such as synthetic androgens and non-synthetic androgens (Steroids) , and so they are able to alter the gene-transcription process in a manner that is tissue specific, in this particular case we are interested in its effects on bone and muscle. Ostarine exerts its effects in a very anabolic way, comparisons have been made with the Anabolic steroid Deca- Durabolin, This is because not only is increased muscle mass seen but it has a very positive effect on joints and bones aswell as nitrogen retention. Now most steroidal androgens convert to DHT or Estrogen so you have the increased chance of DHT related side effects, enlarged prostate for one, and hair loss if your prone, as well as a whole list of other potential DHT related side effects. And Estrogen causes a whole host too, Water retention (Edema), Hypertension (High blood pressure) and the unwelcomed and often hard to treat enlargement of the male breast tissue (Gyno)(2). You also get your own testosterone production shutdown on cycle so a Post cycle therapy protocol is essential to restore correct testosterone levels, even then the ongoing effects of impotence can be seen for many months after full testosterone recovery has been achieved. However those problems along with many others if the steroid of choice is a progestin, can to some degree be eradicated through science, and the development of these new sARMS.
Ostarine (OSTA-SARMS) Doesnt convert to DHT or display any of the side effects by Dihydrotestosterone. In blood tests a slight raise in estrogen levels can be seen, and that might be one of the key factors in its tremendous potential for treating tendon, ligament, and bone injuries or illnesses. It also displays a very anabolic effect on muscle tissue, causing considerbale and easy to maintain gains in muscle over 4-6 weeks, with little to no sides and no real PCT is needed afterwards, just a mild test booster like DAA.
 Another interesting aspect as opposed to your typical steroid is that sARMS remain very hard to detect for Anti-doping agencys as sARMS bypass in effect the well known 4 ring steroid structure, so they are not steroids, but yet sARMS exert many of the same performance enhancing effects that steroids do without the sides (3)
Ostarine, Unleashing its power.
The big question is how do you get the most bang for your buck from Osta-sarms/ MK-2866? Firstly we need to get some facts straight on what it is exactly, its half life and best dose. Ostarine has a half life of 23.8 hours, So a once a day dose is the most effective to get your biggest peak of blood plasma serum levels. Depending on your goals though there are a couple of doses i personaly would recommend.
Anabolic dosing.
Dosing at 24mg-36mg a day gave me my biggest gains in muscle and the best muscle pumps over a 4 week period, going higher than 36mg did not increase the gains in lbm or strength over the same period, for somone weighing 200lbs 24mg is enough to elicit very good anabolism, However for somone weighing above 210lbs, 36mg in experiments i carried out seemed to be a much better dose and offer better general lbm gain, with this dose muscle hardness can be seen to increase after about 6 days.
I suggest front loading Ostarine the first week, Close to double your intended dose, this will speed up the saturation of ostarine in the system and its affect on the androgen receptor.
These very same doses can be used on a cut, with decreased calories to maintain muscle, I highle recommend the use of Osta-sarms in this regard as even in a calorie surplus diet fat loss can be lost at quite a high rate 1-2lb a week, on a cut with added stimulants the loss of viceral fat can be increased exponentialy and muscle tone and hardness will also increase at a rapid rate revealing a ripped and cut physique thats also in a lot better state health wise than if a steroid was used to increase muscle retention during the same period of time.
Bone and tendon repair dosing. One of the outstanding facets of Ostarine is that it doesnt just build muscle, it increases tendon strength, improves the health of the ligaments, increases bone density and increases the rate at wich collagen is turned over. To achieve this a dose of 12mg ed is adequate, and promotes improvement in joint movement that can be seen after just 6-8 days, this dose is very effective for treating injuries like shin splints, and can be used post operation to help maintain muscle and speed up the recovery of the limb, (Bone/Tendon) that has been operated on.
Supplementation while using sARMS.
My favourite supplements wich seem to increase the effectivness of Ostarine are Creatine wich itself increases igf-1 levels,bone density, Lean body mass, and prevents the release of homocysteine thus preventing cardiovascular problems. Zinc and magnesium are a must as both are vital for increase in testosterone levels, androgen receptor sensitivity, and igf-1 levels to remain at a maximal level.
Ostarine in PCT summary.
Remember that you will not fully recover while using Ostarine even at the suggested dose of 10mg a day, which is enough to provide much needed anabolism while allowing recovery, Stopping Ostarine and continuing your pct for a couple of weeks is essential to ensure total recovery from your steroid cycle.
Combining Ostarine with a sERM, and an anti-estrogen , Aromasin or Formestane being my suggestions would be best.
In my next article we will look at the Perfect post cycle therapy with sARM’s
References
1.Selective androgen receptor modulators in preclinical and clinical development.
Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, USA
2.J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):261-6.Prostate cancer risk in testosterone-treated men. Raynaud JP. Université Pierre & Marie Curie, 51 bvd Suchet, Paris 75016, France. 3.Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5.Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 242 L.M. Parks Hall, Columbus, OH 43210, USA
Kindest Regards Russianstar

ATD a potent anti-oestrogen

3,17-dioxo-etiochol-1,4,6-triene
1,4,6-Androstatrien-3,17-dione
1,4,6 etiollochan-dione
Known as: ATD
Half life : 48 hours
Molar mass: 282
What is ATD?
1,4,6-Androstatrien-3,17-dione (ATD) is a potent irreversible A.I that inhibits estrogen biosynthesis by permanently binding and inactivating the Aromatase enzyme in the adipose tissue, (Fat cells) and in the surrounding peripheral tissue.
It can be used on cycle and during PCT to reduce estrogen and help recover natural testosterone production.
ATD has 90% androgenic activity in muscle tissue but only 10% androgenic activity in the hypothalamus. What this means is it helps you hold onto muscle and it also means that ATD blocks the Androgen-Negative-Feed-Back-Loop and aids in decreasing estrogen production while increasing natural testosterone production. Used on cycle it should help reduce shutdown, and prevent estrogen related sides.
How does it work?
There are two main negative feedback loops that we need to consider in PCT. The first is elevated estrogen levels from aromatase activity that will act on the hypothalamus to decrease GnRH production. The second is that elevated androgen levels stimulate androgen receptors in the hypothalamus causing decreased GnRH production. Decreased GnRH leads to reduced LH and FSH production, both of which are directly involved in testosterone production.
ATD combats this in a very interesting way.
ATD works for androgen activity the same way that Serm’s like Nolvadex block estrogen in breast tissue, but allows estrogen to have positive effects in other organs and tissues such as the liver and bone. ATD blocks androgens in the hypothalamus, but allows it to be active in the muscle, By doing this it increases GnRH production, increasing LH and FSH leading to increased testosterone.
ATD also lowers estrogen and is therefore able to increase GnRH from that angle also.
This is how it tricks your body into producing more testosterone.
How can it be used?
Obviously it can be used in PCT, but it has therapeutic affects on cycle, first it only has Anti-androgen affects in the hypothalamus, this means that along with it not interfering with any positive affects from AAS, it also means less shutdown as the androgenic or estrogenic affects of steroids are unable to cause shutdown in the same way as they would without ATD.
As it prevents estrogen and androgens from shutting down GnRH production, less HTPA shutdown takes place, and so recovery after stopping the steroid cycle is much easier.
What does is affective?
25mg a day of ATD on cycle will prevent a large measure of shutdown, obviously depending on what AAS are being used, higher amounts than this can cause severe joint pains and dryness..
During PCT you will notice a surge in libido and then libido drop off, so I suggest starting at 50mg a day, then tapering off this allows for estrogen and androgen levels to return to homeostatis, and it will also prevent estrogen or androgen rebound, prevent Acne and estrogen related rebound sides.
Points of interest.
ATD will give a positive sample as its metabolites are similar to that of the vetinary steroid Equipoise, so please keep this in mind.
Kindest regards Russianstar.

Why Formestane is needed.

This helps show its efficiacy at preventing estrogen and prolactin. http://www.ncbi.nlm.nih.gov/pubmed/20491779
“In cells which expressed ERalpha, formestane/herceptin combination suppressed the mRNA expression of aromatase and HER2 and decreased cyclin D1 expression”
So you know HER2 is to do with prolactin expression. Formastat(tm) contains the suicide aromatase inhibitor formestane (4-hydroxyandrostenedione), a clinically proven anti-estrogen exceedingly more potent than any supplement to come before it. 6-oxo-androstenedione, chrysin, indole-3-carbinol, calcium d-glucarate, trihydroxystilbene, not even our old Viratase (5-alpha-androstanedione) can come close. All of them combined in one capsule still wouldn’t even have a shot. Formastat(tm) is such a revolutionary advance in the area of estrogen suppression because it contains the only agent backed by not one but numerous placebo-controlled human medical studies, and so effective it is actually a prescription breast cancer drug in other countries.

Formestane (4-hydroxyandrostenedione)
Suicide Aromatase Inhibitor
Formastat is in many regards similar to a competitive steroidal aromatase inhibitor like Viratase. Both are steroidal compounds that work by attaching to the active binding site of the aromatase enzyme, preventing it from interacting with other steroids (such as testosterone) that are capable of being converted to estrogen. With the enzyme binding site occupied, it is for all intents and purposes inactive. If the inhibitor is present in a high enough level it will dramatically suppress estrogen concentrations in the blood. The difference between a competitive inhibitor like Viratase, and Formastat, is that the former will detach after some time, rendering the enzyme active again. Formastat on the other hand binds permanently with the aromatase enzyme, making it useless until the body actually replaces it through the normal metabolic attrition of enzymes. This type of compound is called a suicide or irreversible aromatase inhibitor, and has the benefit of being both highly selective in its action on estrogen and long-lasting in effect.
Because of its potent estrogen-suppressing action, 4-hydroxyandrostenedione has been successfully used on breast cancer patients in many other countries including England, Germany, Switzerland, Spain, Australia, New Zealand, Italy and Malaysia12345678 It has been shown to be an effective option as a second line of defense after tamoxifen, an estrogen receptor antagonist, has failed to elicit a positive response with patients, and to produce an overall response statistically similar to tamoxifen when administered as the first-line therapy . Those of us in the bodybuilding world looking to mitigate the physiological effects of estrogen for other purposes have likewise been confronted for the first time with a legal supplement that has all the actions and potency of a pharmaceutical agent, which would normally be obtained only with a doctor’s prescription! .
Dose and Pharmacokinetics
After oral administration peak levels of 4-hydroxyandrostenedione are reached in the blood at approximately 1.5 hours , and the drug is cleared from the body with a half-life of approximately 3 hours . Due to its nature as an irreversible inhibitor, its estrogen-suppressing activity outlives it actual active lifespan in the bloodstream. Studies have demonstrated that maximum estrogen suppression is achieved with an oral dose of only 250mg per day12 . Doubling this dose to 500mg, or even quadrupling it to 1000mg, was shown to have no effect on aromatase inhibition or estrogen levels appreciably different from the 250mg dose.
The Need for Estrogen Maintenance
Estrogen has both positive and negative effects that you should be aware of. On the positive it supports good high density cholesterol, increases muscle glucose utilization for tissue growth and repair, and even increases androgen receptor concentrations in various tissues. It is now understood that estrogen serves many useful purposes in men, particularly if we are looking for rapid muscle mass gain. If bulk is the goal it is therefore usually advised to hold off on estrogen maintenance compounds until there is a clear need for them. This brings us to the negative side of estrogen, namely that it can work to hide muscle definition by increasing water retention and fat buildup. It can also promote gynecomastia (the development of female breast tissue) in men if levels get too high. Since androgens and estrogens playing opposing roles on the disposition of body fat and the growth of mammary tissues, maximizing the ratio between these two hormones is often an important objective, particularly at times when dieting and cutting are key goals or gynecomastia is a worry because strongly aromatized hormones such as testosterone are being supplemented.
Testosterone Stimulation
To spite that fact that 4-hydroxyandrostenedione is also a weak prohormone to the anabolic steroid 4-hydroxytestosterone, as an aromatase inhibitor it also possesses notable testosterone stimulating properties. Whatever weak androgenic activity it may have is more than compensated for by its strong ability to lower estrogen levels. This action of course reduces the suppressive signal estrogen sends to your brain (estrogen is a main feedback signal to control the release of testosterone), increasing the testicular output of testosterone. In-vivo human studies show clearly that 4-hydroxyandrostenedione will suppress estrogen concentrations at levels that were not high enough to suppress gonadotropins13 . Even studies using 250mg to 500mg of 4-hydroxyandrostenedione injected every 2 weeks, or oral doses as high as 1000mg daily, have failed to show any notable suppressive effect towards testosterone concentrations14 . When the drug was given to men, including oral doses as high as 500mg (double the maximum recommended dose), we have seen measurable increases in serum testosterone concentrations 15 16 17. Due to the theoretical potential for androgenic feedback inhibition at high doses we do recommend, however, keeping within the recommended dosage range, and perhaps even limiting the dose to 2-3 caps per day, at times when increasing testosterone levels is a primary focus of use.

Figure 1. Mean testosterone increase in 6 normal men given 500mg of oral 4-hydroxyandrostenedione. Source: Comparison of the pharmacokinetics and pharmacodynamics of unformulated and formulated 4-hydroxyandrostenedione taken orally by healthy men. Cancer Chemother Pharmacol 1990;27(1):67-71
Post-Cycle Use
When used during the recovery window after a cycle of prohormones, or even steroids for that matter, Formastat can offer a very unique additional benefit. The main focus at this time is of course minimizing the post-cycle hypoandrogenic (low androgen) state, mainly by trying to restore the natural production of testosterone, which in many cases has been suppressed by the cycle of hormones. In most cases some type of anti-estrogen is incorporated into an athlete’s recovery program, due to the effect they can have on testosterone release (discussed above). Because Formastat is also a prohormone to 4-hydroxytestosterone, however, it allows for some small level of continued supplementation of exogenous androgen during this window. Normally this would be considered a very bad idea, as androgens are usually suppressive towards testosterone release. But with this product its weak androgenic activity is compensated for by its estrogen suppressing action, so provided reasonable doses are used it can essentially serve as a small bridge to full testosterone recovery. Regular aromatase-inhibitors, of course, cannot offer this benefit.
searl and bell formestat research Cancer Chemother Pharmacol 1990;27(1):99-130
DHT Inhibition
This compound has also demonstrated some ability to inhibit the 5-alpha reductase enzyme in certain in-vitro studies , which would seem to suggest it could offer some benefit by reducing androgenic activity in sensitive target tissues with high concentrations of 5-alpha reductase. At least one study in Scotland, however, suggests that this trait of 4-hydroxyandrostenedione is not strong enough to offer much of a physiological effect . Another makes note of both testosterone and DHT increases in some male patients taking the compound, not testosterone alone, which clearly does not support a strong DHT inhibiting role . We therefore at this time do not have enough evidence to conclude that 4-hydroxyandrostenedione is a potent 5-alpha-reductase inhibiting compound, however will continue to investigate this possible activity.
The Need for Estrogen Maintenance
Estrogen has both positive and negative effects that you should be aware of. On the positive it supports good high density cholesterol, enhances growth hormone output, increases muscle glucose utilization for tissue growth and repair, and even increases androgen receptor concentrations in various tissues. It is now understood that estrogen serves many useful purposes in men, particularly if we are looking for rapid muscle mass gain. If bulk is the goal it is therefore usually advised to hold off on estrogen maintenance compounds until there is a clear need for them. This brings us to the negative side of estrogen, namely that it can work to hide muscle definition by increasing water retention and fat buildup. It can also promote gynecomastia (the development of female breast tissue) in men if levels get too high. Since androgens and estrogens playing opposing roles on the disposition of body fat and the growth of mammary tissues, maximizing the ratio between these two hormones is often an important objective, particularly at times when dieting and cutting are key goals or gynecomastia is a worry because strongly aromatized hormones such as testosterone are being supplemented.
A Naturally Occurring Hormone
4-hydroxylated androgens such as 4-hydroxyandrostenedione have been shown to be naturally occurring, and therefore can be legally sold as nutritional supplements.
REFERENCES:
1 Treatment of advanced breast cancer with formestane. Murray R, Pitt P. Ann Oncol 1994;5 Suppl 7:S11-3
2 Pilot study of formestane in postmenopausal women with breast cancer. Joseph JK, Lim AK. Med J Malaysia 1998 Mar;53(1):37-41
3 Formestane is feasible and effective in elderly breast cancer patients with comorbidity and disability. Venturino A, Comandini D. Breast Cancer Res Treat 2000 Aug;62(3):217-22
4 Formestane versus megestrol acetate in postmenopausal breast cancer patients after failure of tamoxifen: a phase III prospective randomised cross over trial of second-line hormonal treatment (SAKK 20/90). Swiss Group for Clinical Cancer Research (SAKK). Thurlimann B, Castiglione M. Eur J Cancer 1997 Jun;33(7):1017-24
5 Formestane in the treatment of advanced postmenopausal breast cancer. Possinger K, Jonat W, Hoffken K. Ann Oncol 1994;5 Suppl 7:S7-10
6 Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer. Perez Carrion R, Alberola Candel V. Ann Oncol 1994;5 Suppl 7:S19-24
7 An endocrine and pharmacokinetic study of four oral doses of formestane in postmenopausal breast cancer patients. Dowsett M, Mehta A. et al. Eur J Cancer 1992;28(2-3):415-20
8 Formestane is feasible and effective in elderly breast cancer patients with comorbidity and disability. Venturino A, Comandini D. et al. Breast Cancer Res Treat 2000 Aug;62(3):217-22
9 Formestane. A review of its pharmacological properties and clinical efficacy in the treatment of postmenopausal breast cancer. Wiseman LR, Goa KL. Drugs Aging 1996 Oct;9(4):292-306
10 Comparison of the pharmacokinetics and pharmacodynamics of unformulated and formulated 4-hydroxyandrostenedione taken orally by healthy men. Dowsett M, Lloyd P. Cancer Chemother Pharmacol 1990;27(1):67-71
11 Dose-related endocrine effects and pharmacokinetics of oral and intramuscular 4-hydroxyandrostenedione in postmenopausal breast cancer patients. Dowsett M, Cunningham DC et al. Cancer Res 1989 Mar 1;49(5):1306-12
12 An endocrine and pharmacokinetic study of four oral doses of formestane in postmenopausal breast cancer patients. Dowsett M, Mehta A, King N, Smith IE, Powles TJ, Stein RC, Coombes RC. Eur J Cancer 1992;28(2-3):415-20
13 Aromatase inhibitors and hormone-dependent cancers. Brodie AM, Banks PK, Inkster SE, Dowsett M, Coombes RC. J Steroid Biochem Mol Biol 1990 Nov 20;37(3):327-33
14 Dose-related endocrine effects and pharmacokinetics of oral and intramuscular 4-hydroxyandrostenedione in postmenopausal breast cancer patients. Dowsett M, Cunningham DC et al. Cancer Res 1989 Mar 1;49(5):1306-12
15 Aromatase inhibition: 4-hydroxyandrostenedione (4-OHA, CGP 32349) in advanced prostatic cancer. Davies JH, Dowsett M, Jacobs S, Coombes RC, Hedley A, Shearer RJ. Br J Cancer 1992 Jul;66(1):139-42
16 Comparison of the pharmacokinetics and pharmacodynamics of unformulated and formulated 4-hydroxyandrostenedione taken orally by healthy men. Dowsett M, Lloyd P. Cancer Chemother Pharmacol 1990;27(1):67-71
17 Pharmacokinetics of 4-hydroxyandrostenedione in man after intramuscular injection of different formulations and the effect of this drug on plasma aromatizable androgens and 17beta-estradiol concentrations. Danza G, Muratori M, Guarna A, Occhiato EG, Sadri R, Serio M. J Steroid Biochem Mol Biol 1993 Sep;46(3):373-9
18 Aromatase and other inhibitors in breast and prostatic cancer. Brodie AM, Banks PK, Inkster SE, Son C, Koos RD. Steroid Biochem Mol Biol 1990 Dec 20;37(6):1043-8
19 Effects of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites on 5 alpha-reductase activity and the androgen receptor. Davies JH, Shearer RJ et al. J Enzyme Inhib 1992;6(2):141-7
20 A kinetic analysis of the inhibition of human prostatic 5 alpha-reductase by 4-hydroxyandrostenedione and related steroids. Houston B, Habib FK Steroids 1988 Sep;52(3):237-47
21 Aromatase inhibition: 4-hydroxyandrostenedione (4-OHA, CGP 32349) in advanced prostatic cancer. Davies JH, Dowsett M. Br J Cancer 1992 Jul;66(1):139-42
22 Sexual specific C-4 hydroxylation of 5 -androstane-3,17-dione in rats and the influence of the antiandrogen cyproteron acetate. Wenzel M, Pitzel L, Bollert B. Hoppe Seylers Z Physiol Chem 1972 Jun;353(6):861-8

Relative Potency of Type 1 and Type 2 Aromatase Inhibitors

Product

Aromatase Inhibition (%)

Residual Aromatase (%)

Formestane/

4-Androstenoldione

91.9

8.1

Aromasin/Exemestane

97.9

2.1

Cytadren/

Aminoglutethimide

90.6

9.4

Arimidex/Anastrozole

96.7

3.1

Femara/Letrozole

98.7

1.3

Superdrol and prolactin sides. Why Formestane is the answer.

Written by Russianstar, this information is copyrited

Anyone who knows anything about chemical structures will see that superdrol is not a progestin, and shouldnt cause prolactin like side effects.
The problem is everyone is different and eveyone has different amounts of progestin receptors, wich can cause worse sides in some users than others, one guy can use deca and get no bloat, another with the same dose will get bloat and gyno, because of this one reason alone. Now Beastsrol or superdrol is in itself not that androgenic, and as its structure suggests its not that different to other dht based steroids, now an action takes place that explains how it works… its doesnt act like a typical androgenic, but acts a little like oxymetholone, in that it doesnt show any real affinity for the 5AR enzyme, so you get weaker affinty for the androgen receptor than dht, but you get stronger androgenic effects as the enzyme 3beta hydroxysteroid dehydrogenase has little effect on the androgen affinity of superdrol.

The problem is this same enzyme 3beta hydroxysteroid dehydrogenase, is used in the conversion of many metaobiles in the body, Superdrol produces a lot of metabolites that dont get bound by the androgen receptor like we just saw, it cant aromatize, so it doesnt bind to the estrogen receptor, but it circulates, as its also a di methyl, it is very biovailable so a lot of the product circulates in the blood, and these extra metabolites dont bind specificly…not in the way they should.. so i will explain in a detailed way then make it much easier to understand.

Prolactin is normaly caused by progestins, but can also be caused by dht, how?
For example, it is currently understood that when testosterone enters the cell cytoplasm it is subsequently converted to the more “active” androgen, dihydrotestosterone, DHT, by reduction at the 5alpha position, This is normal. Dihydrotestosterone is then either bound to a cytoplasmic “receptor” protein Rc, or is further metabolized to either 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ,DIOL. The binding of DHT to its cytoplasmic receptor protein results in translocation of the steroid-receptor complex into the nucleus where presumably the complex dissociates and DHT exerts its androgenic effects. The transport of DHT to the nucleus can also result from the conversion of testosterone to DHT by nuclear membrane-bound 5alpha-reductase. Prolactin augmentation of DHT effects is envisioned as resulting from interaction of prolactin with its receptor, which due to the large size of the prolactin molecule is probably located in or on the plasma membrane.
Because superdrol is androgenic, but lacks the ability to show affinity via 5ar, it circulates, and this causes the large amounts of androgens to look for a transporter, so that it can bind to the androgen recptor, so it uses prolactin wich has a high affinity to cytoplasmic receptor protein, allowing the androgens, testosterone, to be carried and allowing them to convert to dht, only problem is prolactin hormone or luteotropic hormone is synthesised and secreted by sex binding lactotrope cells in the adenohypophysis (anterior pituitary gland, And this gland now produces more prolactin to help deal with the large amount of testosterone circulating that hasnt bound to the estrogen of androgen receptor, Part of the reason why superdol is so anabolic, So instead of binding to the androgen receptors in the scalp and the prostrate it converts to dht through this unique process, using prolactin to enter the cytoplasmic receptror protein, and allowing it to convert to dht and then bind to the androgen receptors in the muscle, causing its distinct hardening effects, it still cant bind to the scalp or prostrate via 5ar as the form of dht it has converted too doesnt allow for that affinity.
So more prolactin is produced to allow for the superdol to find a receptor ,this excess prolactin triggers a process that fills the breast with milk via a process called lactogenesis, in men however it causes a distinct enlargment of the mammary gland and can even cause a man to lactate.

If superdrol had better binding to the androgen receptor via 5AR then this problem would be prevented, the other thing is that prolactin production can remain elevated for months after a cycle has finished, and once the androgen has been removed, ( the cycle is over) the cytoplasmic receptor proteins have nothing to do other than to allow the prolactin to proceed with its hormonal action within the body, causing the male mammary gland to enlarge ready to produce milk… Hence the REBOUND gyno, this is why proper pct is needed for superdrol, and the use of something to prevent prolactin.

I suggest using topical Formestane.

Now the best bit is this, There are references as that show that DHT applied in areas with high prolactin can reduce gyno. Here is one:

Benveniste O, Simon A and Herson S. Successful percutaneous dihydrotestosterone treatment of gynecomastia occurring during highly active antiretroviral therapy: four cases and a review of the literature. Clinical Infectious Diseases 2001;33:891-893.

This shows that when in this case dht, but anything strongly androgenic in its actions is applied to gyno where high levels of prolactin are found then gyno can be reduced!!! Now this will work with prolactin induced gyno, as this and at least 6 other studies show.
So not only can Formastane  improve gyno the same way masteron can, by preventing estrogen from binding to the estrogen receptor, it can also reduce the size of prolactin induced gyno, as it lowers the amount of progestin receptors available, and seems to act as a slight dopmamin agonist.

Now you will see many companies add pregenelone to formestane to reduce the androgenic activity, but it aslo reduces it effects considerably.
Taken oraly it has little effect, but transdermaly it is extremely potent, in fact its used to treat breast cancer as It is available as an intramuscular depot injection , some of you maybe aware called lentaron.

So how does it work exactly, Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers, And transdermaly formestane is one of the strongest products for this, so that means lean ROCK HARD gains on cycle. This is because the androgens can no longer convert into estrogen.. thats good news as it doesnt act like exemestane wich form a permanent bond with the aromatase enzyme, so preventing any estrogen wich is bad for your joints and tendons.

So why does gyno happen on cycle?

Bodybuilders who use steroids may experience an increase in estrogen levels , and this has undesirable consequences for a bodybuilder, such as gynecomastia. This is often the case when a natural aromatase inhibitor 4-OHAD has itself been inhibited. 4-OHAD is a metabolite of testosterone, which can mean 4-OHAD remains inhibited whilst aromatase levels are allowed high, so you actualy get even less androgens than normal and higher estrogen levels, so using Forma-Stanozolol can change the ratios allowing the enzyme 4-OHAD to remain active, so limiting estrogen, by increasing testosterone itself through its AI activity, And by preventing estrogen from binding to receptors so preventing gyno, but as it allows some estrogen to circulate, tendons and ligaments are kept strong and healthy.

It has a 12 hour half life wich is great as when used just morning and night it will build up even plasma levels in the blood and be constantly active, so getting full benefits of its AI properties, And through its special abilty to stimulate the dopaminergic system, it can prevent prolactin.. so it actualy can PREVENT GYNO BOTH FROM PROLACTIN AND ESTROGEN, and be used to TREAT GYNO FROM PROLACTIN through its abilty to act as a dopamine agonist, its ability to lower progestin receptor count, and its androgenic properties, And be used to TREAT GYNO CAUSED BY HIGH AROMATISATION.

Yes Formastane could even be used to treat and prevent DECA droopiness.

But i havent finished, one more thing makes this perfect not only alone or on cycle but especialy through PCT when estrogen levels rise, problem is if you block estrogen off you get low igf-1 levels…  formestane can increase igf1 levels by a whopping 26 percent!!!

And you know i said it was androgenic… well it is, but it also can reduce BPH, so it even protects your prostrate!!!

And as its a transdermal, you may want to rub it all over your nips for improved action, you see i love milk, but i dont want to make my own, in fact i like boobies but i dont want to grow my own, and FORMASTANE can reduce your chances of either of these ever happening, and believe me for those whove experienced both the former happening, its not nice!!!

So not only is formastane perfect for any cycles using aromatizing compounds, but its perfect for anything that produces prolactin or is progestenic.. It will reduce any sides, or bloat and allow pct to be much easier and more effective.

 

 

From these studies and all the logs of formestane available on the internet these are the facts.

  • Formestane increases IGF-1 secretion and activity.
  • Formestane decreases the number of progesterone receptors (inhibits the trenbolone and “deca-dick” type side effects and increases fat loss)
  • Formestane inhibits 91.9% of aromatase enzyme production
  • Formestane increases HPTA activity similar to HCG and Clomid together
  • Formestane is anabolic and androgenic
  • Formestane is a “suicide inhibitor” of aromatase. Specifically this means that it will irreversibly bind to the aromatase enzyme and permanently deactivate it
  • Formestane (The sterile injectable form) possesses a 4-day half-life
  • Formestane decreases SHBG 34% thus increasing androgen activity.
  • Formestane inhibits DHT (dehydrotestosterone) formation and activity.
  • Formestane possesses 1% of the binding affinity of DHT to DHT receptors
  • Formestane has been shown to decrease prostate concerns such as BPH.
  • Formestane has been shown to continue to increase HPTA function above natural levels even after 22 weeks of continuous administration
  • Kindest regards RS

R.S